Your students have heard about CRISPR, now, they can model how this protein can modify DNA. With Making the Cut with CRISPR-Cas9:copyright:’s colorful foam pieces and placemat your students can build an interactive model of the CRISPR-Cas9 RNA-guided endonuclease, including the viral double-stranded DNA and dual guide RNA. You can observe students transferring their prior knowledge of DNA structure while modeling how the Cas9 protein functions.
- Build a schematic model of the CRISPR-Cas9 RNA-guided endonuclease, including the viral double-stranded DNA and dual guide RNA
- Understand how the Cas9 protein binds to a specific sequence of viral double-stranded DNA at a PAM site - and cuts it
- Demonstrate how that cut destroys the viral genome and prevents the infection of bacteria
- Amplify their learning with student handouts and digital materials
You can observe students transferring their prior knowledge of DNA structure while modeling how the Cas9 protein functions.